Jaundice associated with naproxen.

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Jaundice associated with naproxen.

Hepatic injury in association with naproxen therapy is described and documented by liver biopsy in one patient. Histological findings were consistent with a drug-induced hepatitis, and cessation of therapy led to reversal of the clinical and biochemical changes. Circumstantial evidence is in favour of a hypersensitivity response to the drug rather than direct hepatotoxicity. Increased awareness...

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Neonatal Jaundice Associated with Familial

It is now well established that hyperbilirubinaemia and even kernikterus may occur in the newborn in association with glucose 6 phosphate dehydrogenase (G6PD) deficiency, in the absence of any of the other causes of neonatal jaundice (Panizon, 1960a, b; Doxiadis, Fessas, and Valaes, 1960; Doxiadis, Fessas, Valaes, and Mastrokalos, 1961; Fessas, Doxiadis, and Valaes, 1962; Smith and Vella, 1960;...

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Naproxen-associated vasculitis.

Three cases of digital vasculitis attributable to naproxen ingestion are reported. The vasculitic changes were reversed by withdrawal of the drug. These three cases emphasize the need to consider drug sensitivity as a cause of unexplained digital vascular lesions.

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Obstructive Jaundice Associated with Polcystic Liver Disease

A 65 year old patient with polycystic liver disease presented with obstructive jaundice thought to be a cholangiocarcinoma. Subsequent investigations demonstrated a large cyst compressing the confluence of the hepatic ducts. Percutaneous decompression of the biliary tree led to a complication necessitating surgery. Treatment options for symptomatic polycystic liver disease are reviewed.

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After spontaneous vaginal delivery, a 32-week-gestation female baby presented immediately with respiratory distress, APGAR scores 0 (1 min) and 2 (5 min), generalized skin oedema and bilateral pleural effusion. The prenatal history was unremarkable. The clinical diagnosis was nonimmune hydrops fetalis, and treatment with mechanical ventilation, surfactant, prostaglandin and supportive measures ...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1980

ISSN: 0032-5473

DOI: 10.1136/pgmj.56.655.368